Representative ICl.Ca was respectively recorded in the mVMs under the normoxic (A,a and B,a), hypoxic (A,b and B,b) conditions and in the presence of inhibitors (A,c and B,c). (A,d and B,d) Summarized densities of ICl.Ca were plotted against membrane potentials; ICl.Ca was significantly up-regulated by hypoxia and was dramatically inhibited by a specific pore-targeting anti-ANO1 antibody (n = 6) and T16Ainh-A01 (n = 5).