Fig. 1.

Kidney histology in rodent NASH. Representative H&E-stained kidney sections from rat (A) and mouse (B) NASH models. A significant number of protein casts was present in the kidneys of fa/fa rats (2A; arrow). Images were taken at 20× magnification. . Higher magnification (100×) images of glomerular changes were captured and shown as an insert to each figure. (C) Pathologic scoring evaluations describing total kidney injury scores are shown. Horizontal bar represents the median of data (N = 4 animals) and *P ≤ 0.05 versus control within each group. Data were ranked-ordered before statistical analysis. Scoring key: 0, none; 1, minimal (<10% affected); 2, mild (10–25% affected); 3, moderate (25–40% affected); 4, marked (40–50% affected); 5, severe (>50% affected).