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. 2015 Jan 14;35(2):474–484. doi: 10.1523/JNEUROSCI.1828-14.2015

Figure 2.

Figure 2.

Leptin microinjection into the hypothalamic ARC increases hepatic sympathetic outflow in rats. A, B, Representative neurograms (A) and time course data (B) depicting the Liv-SNA response to intra-ARC or -VMH injection of vehicle and leptin (0.5 μg). C, Microphotographs of coronal rat brain sections showing restricted presence of the dye after comicroinjection with leptin into the ARC (counterstained with DAPI; top) or VMH (bottom). D, E, Representative neurograms (D) and time course data (E) of Liv-VNA response to intra-ARC injection of vehicle and leptin (0.5 μg). F, G, Western blot analysis of phosphorylated and total levels of Akt in the ARC 30 min after ICV injection of vehicle or leptin. Data are presented as mean ± SEM; n = 5–7 per group. *p < 0.05 versus vehicle group.