Table 2.
Membrane properties of WT and SOD1G93A OMNs classified by predicted MU type
| Membrane property | PS |
PF |
||
|---|---|---|---|---|
| WT (n = 10) | SOD1G93A (n = 9) | WT (n = 11) | SOD1G93A (n = 8) | |
| Cm, pF | 114.2 ± 8.6 | 105.1 ± 7.7 | 161.1 ± 10.4 | 163.3 ± 10.1 |
| Rinp, MΩ | 97.3 ± 10.6 | 123.5 ± 16.5 | 37.2 ± 3.5 | 47.0 ± 4.5 |
| RMP, mV | −56.9 ± 1.8 | −57.9 ± 1.3 | −59.1 ± 1.2 | −59.3 ± 1.0 |
| Rheobase, pA | 162.0 ± 17.3 | 113.9 ± 20.0 | 400.0 ± 27.0 | 368.8 ± 32.6 |
| AP threshold, mV | −43.7 ± 1.9 | −42.4 ± 2.0 | −40.8 ± 1.7 | −40.5 ± 1.4 |
| AP height, mV | 88 ± 3.6 | 87.6 ± 2.3 | 93.7 ± 1.8 | 92.0 ± 2.9 |
| AP half-width, ms | 0.9 ± 0.1 | 1.0 ± 0.1 | 0.7 ± 0.03 | 0.7 ± 0.04 |
| AHP, mV | −4.7 ± 1.2 | −7.2 ± 1.6 | −2.8 ± 0.3 | −2.6 ± 0.4 |
Values reported as mean ± SEM. Student t tests were performed for statistical comparison between WT and SOD1G93A neurons within the two predicted MU types.