Table 1.
PAR1-dependent increases in calcium influx are diminished by inhibiting glial metabolism
| Condition | (ΔF/F)% | n |
|---|---|---|
| Neurons | ||
| Control | 14.1 ± 1.3 | 39 |
| Fluorocitrate | 3.0 ± 1.5* | 30 |
| Astrocytes | ||
| Control | 25.7 ± 1.5 | 121 |
| Fluorocitrate | 4.8 ± 1.8** | 28 |
PAR1 was activated by bath application of SFLLRN-NH2. Peak responses were determined for each cell type. FC significantly inhibited the responses of both neurons and astrocytes to PAR1 activation. (Unpaired t test within each cell type;
* p < 0.05 compared with the control neuronal response;
** p < 0.05 compared with the control glial response.)