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. 2015 Feb;352(2):227–235. doi: 10.1124/jpet.114.220418

Fig. 5.

Fig. 5.

Effect of peptides on lipolysis in serum. (A) A wide range of serum samples from 20 hypertriglyceridemic patients (TG = 207–716 mg/dl) were incubated in vitro with LPL alone (0.2 U) or LPL plus C-II-a peptide (10 μmol/l), and the appearance of FFAs was measured. Representative results from six patients are shown. (B) Mean percentage change in FFAs after addition of LPL (●) compared with baseline (no LPL) or LPL plus C-II-a peptide (▪) compared with LPL only baseline in hypertriglyceridemic serum. (C) Mean percentage change in FFAs after addition of LPL and C-II-a peptide (50 μmol/l) or full-length apoC-II protein (10 μmol/l) compared with LPL only baseline for hypertriglyceridemic serum samples (n = 9), with a mean TG level of 314 mg/dl (range, 224–436 mg/dl). Results represent the mean of triplicates ± S.D. *P < 0.05 compared with baseline.