Fig. 7.

Effect of apoC-II mimetic peptides on lipids in apoE-knockout mice. ApoE-knockout mice (female; n = 3 per group) received an intravenous bolus injection of C-II-a or C-II-i peptide (30 mg/kg). Retro-orbital bleedings were performed up to 4 hours postinjection. Fast-protein liquid chromatography separation and lipid analysis were performed on pooled samples for triglycerides (A, C, and E) and cholesterol (B, D, and F). Results represent the mean of triplicates ± S.D. *P < 0.05 compared with baseline. IDL, intermediate-density lipoprotein.