TABLE 1.

Effects of R1 on the activity of MPO and the levels of TNF-α and IL-6 in mice with DSS- or TNBS-induced colitis

Colon segments from mice (n = 6 per group) were excised and homogenized. The supernatants were assayed for the determination of the activity of MPO and the levels of TNF-α and IL-6 as described in Materials and Methods. Values are expressed as the mean ± S.D.

Group	DSS			TNBS
	TNF-α	IL-6	MPO	TNF-α	IL-6	MPO
	pg/mg protein		U/mg protein	pg/mg protein		U/mg protein
Vehicle	14.6 ± 1.7	28.9 ± 2.3	3.7 ± 0.6	27.4 ± 1.2	39.7 ± 3.3	2.8 ± 0.2
R1	16.96 ± 1.1	23.79 ± 4.1	3.2 ± 0.2	30.9 ± 3.6	35.8 ± 1.9	3.1 ± 0.3
DSS/TNBS	127.4 ± 8.5	214.3 ± 17.9	26.8 ± 2.2	86.6 ± 6.4	119.7 ± 7.9	15.3 ± 1.7
DSS/TNBS + R1	61.5 ± 3.9**	164.2 ± 16.6*	11.4 ± 1.8**	52.2 ± 4.1**	86.3 ± 7.4*	8.8 ± 0.7*

^*P < 0.05; **P < 0.01 versus DSS- or TNBS-treated group.