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. 2015 Feb;352(2):208–217. doi: 10.1124/jpet.114.219873

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Fig. 2. — Depression of ICSS by 1.8% lactic acid. (A) The left panel compares effects of pretreatment with vehicle plus vehicle and vehicle plus 1.8% lactic acid on full frequency-rate curves for all 35 rats used in the first phase of ICSS experiments. Abscissa: frequency of electrical brain stimulation in hertz (log scale). Ordinate: ICSS rate expressed as %MCR. Two-way ANOVA indicated a significant main effect of frequency [F_(9,306) = 295.4, P < 0.001] and acid treatment [F_(1,34) = 86.8, P < 0.001], and the interaction was also significant [F_(9,306) = 10.2, P < 0.001]. The acid noxious stimulus significantly depressed ICSS at all frequencies (Holm–Sidak post hoc test, P < 0.05). (B) The right panel shows summary data for lactic acid effects on the total number of stimulations per component. Abscissa: pretreatment condition. Ordinate: percent baseline number of stimulations per component. The downward arrow indicates that lactic acid produced a significant decrease in ICSS at one or more frequencies in the full frequency-rate curve. LA, lactic acid; Veh, vehicle.