Fig. 4.

Effects of bitopertin on actions of TCN 201. (A) Bitopterin augmented NMDA EPSPs in an irreversible manner. (B) After augmentation of NMDA EPSP by 100 nM bitopertin, TCN 213 (10 µM; solid bar) only partially depressed NMDA EPSPs but administration of ifenprodil (10 µM; open bar) failed to further depress NMDA EPSPs. D-APV (5 µM; hatched bar) depressed NMDA-EPSPs. Traces to the right of the graph show NMDA EPSPs at the times denoted with initial control responses shown as dashed lines. In (B), the response with bitopertin alone (at 25′) is shown as solid line. Values are expressed as the mean ± S.E.M. N = 5 for each experiment. Calibration: 1 mV; 5 milliseconds.