Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
Control (n = 6) or chimeric TK-NOG mice (n = 6 per group) were treated with 32 or 6 mg/kg per day bosentan by mouth or vehicle (n = 3) for 14 days, and their plasma ALT (A) and alkaline phosphatase (B) levels were measured on days 0, 7, and 14. Each bar is the average + S.D. of the measurements in control or humanized TK-NOG mice, and the dashed line indicates the upper limit of normal for the measured parameter.
