. 2015 Feb;87(2):197–206. doi: 10.1124/mol.114.095471

TABLE 3.

LDK1229 binding to the T210A, wild-type, and T210I CB₁ receptors using [³H]CP55,940 as a tracer

	K_i^a
	CP55,940	K_i Ratio^b	LDK1229	K_i Ratio^b
	nM
CB₁ T210A	7.00 (2.59–18.9)	1:3	NB	—
CB₁ wild type	2.56 (1.45–4.51)^c	1:1	220 (106–457)	1:1
CB₁ T210I	0.835 (0.542–1.29)	3:1	5831 (907–7510)	1:27

NB, no binding using up to 32 μM of LDK compound.

^{^a}

Data are the median and corresponding 95% confidence limits of three independent experiments performed in duplicate. K_i values were determined from competition binding assays using [³H]CP55,940 as tracer at its respective K_d values, as described in Results.

^{^b}

Wild type:mutant.

^{^c}

Binding values are from Ahn et al. (2009) for comparison.