TABLE 1.
Inhibitory efficacy of mono- and difluorobenzoates on hKCa3.1
Data are derived from inside-out patch-clamp experiments on hKCa3.1 stably expressed in HEK293 cells. Data are given as mean ± S.E.M., n ≥ 3.
| Compound |
IC50 |
Control at 1 μM |
Control at 5 μM |
Control at 10 μM |
|---|---|---|---|---|
| % | ||||
| 4-Amino-3-fluorobenzoic acid | NT | NT | 90 ± 3 | |
| 4-Hydroxy-3-fluorobenzoic acid | NT | NT | 80 ± 8 | |
| 1,3-Phenylenedimethanol | NT | NT | 106 ± 8 | |
| RA-1 | 94 ± 1 | 87 ± 2 | NT | |
| RA-2 | 17 ± 3 nM | 4 ± 1 | NT | NT |
| RA-3 | 6 ± 2 nM | 12 ± 2 | 2 ± 1 | NT |
| RA-4 | 15 ± 6 | NT | NT | |
| RA-5 | 97 ± 2 | 94 ± 1 | NT | |
| RA-6 | 83 ± 3 | 74 ± 11 | NT | |
NT, not tested.