Table 1.
The clinical courses of eight patients who received chemotherapy with docetaxel and cisplatin as part of multimodal treatment
| No. | Age | Sex | PS | Stage (TMN) | Surgery | Radiation | Objective of DC therapy | Response | Coursesa | Survival (weeks) | TTP (weeks) |
|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | 64 | M | 0 |
IVB (T4bN1bM0) |
TT+ND | 60 Gy | Postoperative adjuvant | NE | 5 | 180 | 157 |
| 2 | 62 | F | 0 | LN(b) | ND | 60 Gy | Postoperative adjuvant | NE | 6 | 280 | d |
| 3 | 58 | F | 0 |
IVC (T4bN1bM1) |
LT+ND | – | Induction chemotherapy | PR | 4 | 27 | 21 |
| 4 | 47 | M | 0 | LNb | ND | 60 Gy | Distant metastasis | SD | 6 | 42 | 29 |
| 5 | 70 | M | 0 |
IVB (T4bN0M0) |
LT+ND | CRT 40 Gy | Distant metastasis | PR | 5 | 91 | 24 |
| 6 | 58 | M | 0 |
IVC (T4bN1bM1) |
LT | – | Distant metastasis | PR | 6c | 227 | d |
| 7 | 70 | M | 1 |
IVC (T4bN1bM1) |
TT+ND | – | Distant metastasis | SD | 5 | 52 | 23 |
| 8 | 72 | F | 0 |
IVC (T4bN1bM1) |
TT+ND | CRT 40 Gy | Distant metastasis | SD | 6 | 174 | d |
PS performance status, TT total thyroidectomy, LT lobectomy, ND neck dissection, CRT chemoradiotherapy consisted of 40 Gy irradiation plus cisplatin, 5-fluorouracil and doxorubicin, TTP time to progression, NE not evaluable, PR partial response, SD stable disease
aNumber of courses of chemotherapy completed
bMetastatic anaplastic cancer component in lymph nodes
cAfter six cycles of DC therapy, this patient was switched to single-agent docetaxel every 4 weeks for 30 cycles
dNo progression