Fig. 1.

Properties and effect of the FATT mutation in vivo. a Weekly body weights of male mice in “C” generation (grandparental offspring of a cross between A1 and A3). Results are shown as the mean (±STDEV). Mice were grouped as “normal” or obese at 12 weeks of age (normal n = 5, obese n = 4). b LR and LR-FATT alternatively spliced transcripts. Sequence differences suggest the existence of two alternatively spliced transcripts: LR-FATT1 (a 291-bp deletion corresponding to the entire coding region of exon 7) and LR-FATT2 (retains 152 bp of intron 7 sequence between exons 7 and 8). c Putative LR-FATT proteins compared to wild-type and LR db receptors. The wild-type full-length receptor (LRb) contains all described domains of the leptin receptor. The IGD main is excised from LR-FATT1, while LR-FATT2 is truncated just after this domain. The LR db receptor is truncated after box 1. CRH cytokine receptor homology, IGD immunoglobulin-like, FN III fibronectin type III, Y tyrosine