Table 1.
Phenotype data for wild-type (+/+), heterozygous (fatt/+) and obese (fatt/fatt) FATT mice at 10–11 weeks of age
| Sex | Males | Females | ||||
|---|---|---|---|---|---|---|
| Genotype | +/+ | fatt/+ | fatt/fatt | +/+ | fatt/+ | fatt/fatt |
| N | 5 | 8 | 8 | 6 | 7 | 4 |
| Body weight (g) | 23.23 ± 2.68 | 23.39 ± 3.08 | 46.28 ± 3.86**## | 16.63 ± 1.07 | 18.60 ± 2.16 | 38.92 ± 2.80**## |
| Body length (cm) | 8.23 ± 0.74 | 8.28 ± 0.33 | 9.27 ± 0.27**## | 7.28 ± 0.18 | 7.41 ± 0.59 | 8.70 ± 0.43**## |
| Femur length (mm) | 15.00 ± 0.71 | 14.94 ± 0.62 | 14.42 ± 0.20 | 13.75 ± 0.69 | 13.86 ± 0.85 | 13.50 ± 0.50 |
| Femur (mg) | 35.93 ± 7.14 | 34.95 ± 6.00 | 36.45 ± 1.83 | 27.57 ± 5.64 | 27.63 ± 3.85 | 29.24 ± 2.83 |
| Liver (mg) | 905.50 ± 158.74 | 905.80 ± 123.58 | 1,551.70 ± 251.42**## | 589.30 ± 55.61 | 694.60 ± 83.44* | 1,068.80 ± 96.52**## |
| Liver (mg/body weight) | 38.80 ± 2.95 | 39.10 ± 5.97 | 33.60 ± 5.81 | 35.60 ± 4.85 | 37.4 ± 2.55 | 27.70 ± 3.89**## |
| Gonadal WAT (% of body weight) | 1.47 ± 0.10 | 1.86 ± 0.41 | 5.83 ± 0.77**## | 2.04 ± 0.68 | 3.46 ± 1.19* | 11.56 ± 0.53**## |
| Retroperitoneal WAT (% of body weight) | 0.28 ± 0.06 | 0.34 ± 0.08 | 2.38 ± 0.25**##G | 0.25 ± 0.07 | 0.42 ± 0.16 | 1.66 ± 0.31**##G |
| Subcutaneous WAT (% of body weight) | 0.99 ± 0.31 | 1.09 ± 0.14 | 4.80 ± 0.64**##G | 1.7 ± 0.52 | 2.24 ± 0.86 | 5.43 ± 0.28**## |
| Visceral WAT (% of body weight) | 2.10 ± 0.3 | 2.01 ± 0.38 | 3.85 ± 0.72**## | 1.96 ± 0.39 | 2.26 ± 0.25 | 3.42 ± 0.33**## |
| BAT(% of body weight) | 0.36 ± 0.08 | 0.35 ± 0.05 | 0.74 ± 0.25**## | 0.34 ± 0.09 | 0.40 ± 0.050 | 0.75 ± 0.16**## |
| Glucose (mM) | 5.25 ± 1.66 | 5.79 ± 1.03 | 12.50 ± 3.40**##G | 4.03 ± 0.97 | 4.89 ± 0.60 | 4.72 ± 1.18 |
| Insulin (ng/ml) | 0.79 ± 0.23 | 0.71 ± 0.47 | 73.10 ± 24.95**##G | 0.31 ± 0.21 | 0.58 ± 0.31 | 26.91 ± 12.71**##G |
| Leptin (ng/ml) | 7.10 ± 5.28 | 7.92 ± 6.51 | 116.36 ± 29.72**## | 5.82 ± 3.60 | 7.98 ± 3.71 | 103.65 ± 25.51**##G |
| Age (days) | 74.50 ± 3.0 | 75.80 ± 3.74 | 75.83 ± 2.86 | 72.17 ± 1.60 | 73.14 ± 3.24 | 73.00 ± 4.00 |
Results are displayed as average ± standard deviation
WAT white adipose tissue, BAT brown adipose tissue
Tukey’s HSD test used in all analysis unless noted, Games–Howell test (G): significance is denoted as * P < 0.05 versus +/+, ** P < 0.001 versus +/+, # P < 0.05 versus fatt/+, ## P < 0.0.001 versus fatt/+. Differences are not significant unless noted