Fig. 2.

Fraction of viruses from vaccinees and placebo recipients with designated residues at V3 position 307 and V2 position 169 (A), and with designated residues at V3 position 317 and V2 position 181 (B). The vaccine immunogen amino acid is represented by the bottom-most bar in each plot. For all positions except Env 169, the amino acid was the same in all three immunogen sequences; at Env 169 the MN immunogen AA (methionine) was not found in any subject's breakthrough sequence so it is not depicted.