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. 2014 Oct 13;6(1):35–44. doi: 10.1016/j.jare.2014.09.001

Table 2.

Concentration (μM) of some coumarins necessary to inhibit the activity of Helicobacter pylori urease by 50%.

Inline graphic
Compound R1 R2 R3 R4 R5 R6 IC50 (μM)
1 H OH H H H H 58.9
2 H CH3 H H OH OH 54.6
3 H H H CH3 OH H 68.9
4 H CH3 H H OH H 72.6
5 H OH H CH3 H H 70.7
6 H CH3 H OH H H 61.9
7 H C6H5 H H OH H 48.9
8 H C6H5 OH H OH H 53.9
9 H C6H5 H H OH OH 55.3
10 C6H5 OH OH H OH H 47.8