Table 2.

Ascididemin derivatives along with mean IC₅₀ of 12 different cell lines viz., two colon (HCT-15; LoVo); two breast (T-47D and MCF7); three glioblastomas (SW1088; U-373 MG and U-87 MG); one prostate (PC-3); two bladder (J82; T24) and two non small-cell lung (A549; A-427) cancer cell lines.

Compound	R1	R2	R3	Mean IC50 (nM)
5	NH2	H	H	53
6	H	Br	H	80
7	H	NH2	H	21
8	H	NHCH2CH2Cl	H	7
9	H	N(CH2CH2Cl)2	H	100
10	H	NHCH2CH2N(CH3)2	H	60
11	H	Cl	H	270
12	H	CH3	H	60
13	H	OCH3	H	90
14	H	N(CH3)2	H	37
15	H	NHBn	H	140
16	H	NH2	Br	140
Ascididemin	H	H	H	100