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. Author manuscript; available in PMC: 2016 Jan 15.
Published in final edited form as: Bioorg Med Chem Lett. 2014 Nov 29;25(2):225–228. doi: 10.1016/j.bmcl.2014.11.066

Table 1.

Inhibitions of [3H]TCP binding (%) at the PCP site of the NMDA receptor, binding affinities (Ki), and clogD values for 1 and 2.

graphic file with name nihms-650371-f0003.jpg
Ligand R Inhibition (%)a [3H]TCP Ki (nM)b cLogDc
1 (CNS1261) I 106 31.9 2.76
2 SMe 93.1 39.8 2.49
a

Inhibition at 1.0 μM concentration (mean from two experiments).

b

Mean from two experiments.

c

Calculated using ACD Labs program.