Skip to main content
. Author manuscript; available in PMC: 2015 Jul 1.
Published in final edited form as: J Clin Immunol. 2014 Apr 24;34(0 1):S80–S85. doi: 10.1007/s10875-014-0020-9

Fig 4. IVIG regulates plasma and hippocampal levels of antioxidant mRNAs in 3xTg mice.

Fig 4

A) IVIG increases plasma levels of select mRNAs regulating detoxifying antioxidant pathways. Bar graph shows that six months of placebo treatment resulted in a 40–60% reduction in the expression levels of transcripts encoding superoxide dismutase 2 (SOD2), catalase (CAT), glutathione S-transferase 1 (GST1), and glutathione peroxidase 1 (GPX1) compared to baseline, whereas six months of IVIG treatment preserved the levels of these antioxidant enzyme transcripts. n = 12/group *, p < 0.01 compared to baseline, **, p < 0.001 compared to baseline, via one-way ANOVA with Bonferroni’s post hoc test for multiple comparisons. B) Antioxidant transcript levels are also preserved in the hippocampus of IVIG-treated mice. Bar graphs show relative expression levels of SOD2, GST1, and carbonyl reductase 1 (CBR1) in placebo and IVIG-treated mice compared to baseline, as quantified by qPCR. SOD2 and GST1 levels were reduced by ~40% in placebo-treated mice, whereas levels of these transcripts were unchanged in IVIG-treated mice. n = 6/group *, p < 0.05 compared to baseline, via one-way ANOVA with Bonferroni’s post hoc test for multiple comparisons. Other abbreviations: SOD1 (superoxide dismutase 1), GSR (glutathione reductase), GLRX (glutaredoxin).