Table 4.
Selected studies of impaired glucose tolerance [IGT], including diabetes mellitus, in patients with DISH.
| Author | No. of Patients | Dish Criteria | Diabetic or IGT | Diabetic | IGT | Comment |
|---|---|---|---|---|---|---|
| Boulet et al. [1954] [29] | 8 M, 4 F | “Forestier” | 100% | 100% | NS | No controls, small sample |
| Recordier et al. [1959] [41] | 16 persons | “Forestier” | 56% | NS | NS | No controls, small sample |
| Einaudi et al. [1960] [42] | 15 M, 4 F | NS | 60% + | 60% | “many” | No controls, small sample |
| Cassan [1963] [43] | 43 persons | NS | 23% | NS | NS | 6.5% controls |
| Ott et al. [1963] [44] | 100 persons | NS | 50% | 25% | 25% | Suggests association of DISH with abnormal GT |
| Dahmen [1967] [45] | 120 persons | “Forestier” | 30% | 20% | 10% | 7.3% controls, suggests association with abnormal GT |
| Ott et al. [1967] [46] | 160 persons | NS | 55% | 22% | 33% | No controls but high prevalence abnormal GT |
| Perrotin [1968] [47] | 59 persons | NS | 61% + | 61% | NS | No controls but high prevalence abnormal GT |
| Lequesne et al. [1970] [48] | 43 persons with DISH, 46 without DISH | “Forestier” | DISH = 23% Control =6.5% [p<0.05] |
DISH = 23% Control =6.5% [p<0.05] |
NS | Significant association between DISH and diabetes |
| Julkunen et al. [1971] [3] | 94 M, 70 F with DISH / same number without DISH | Julkunen | DISH M 19.1% DISH F 28.6% Control M 7.4% Control F 12.8% [p < 0.05] |
NS | NS | Significant association between DISH and hyperglycaemia |
| Bregeon et al. [1973] [49] | 21 persons | “Forestier” | 43% | 30% | 13% | No controls |
| Henrard and Bennett [1973] [50] | 48 DISH 35 non-DISH Pima Indians |
“Forestier” | 50% DISH 28% non-DISH [p<0.05] |
NS | 50% had OGTT, 2hr glucose> 160mg% | Significant association between DISH and hyperglycaemia |
| Harris et al. [1974] [4] | 17 M, 17 F | Harris | 8.5% + | 8.5% + | Only 6 tested- all “normal” | No controls |
| Utsinger et al. [1976] [32] | 25 M, 5 F | Resnick | 17% | NS | Fasting hyperglycaemia | No controls |
| Rosenthal et al. [1977] [51] | 50 persons | Resnick | 32% | NS | NS | No controls |
| Tsukamoto et al. [1977] | 157 M, 18 F | Resnick | “no correlation between DISH and diabetes” in males | NS | NS | Hiroshima survivors |
| Resnick et al. [1978] [33] | 21 M | Resnick | 29% | NS | NS | No controls |
| Arlet et al. [1978] [52] | 100 M | “Forestier” | 14% | 9% | 5% | No controls |
| El Garf and Khater [1984] [53] | 38 persons | Resnick | 37% | NS | NS | No controls |
| Cassim et al. [1990] [54] | 21 persons DISH 479 no DISH |
Resnick | 52.4% | 33.3% history DM in DISH, 7.7% in controls [p<0.0001] |
19.1% IGT to glucose load | High diabetes in DISH group, but small number of patients |
| Troillet and Gerster [1993] [35] | 17 M, 8 F DISH 17 M, 8 F no DISH, matched for age, BMI. |
Resnick | No difference | No difference | Fasting hyperglycaemia | IGT not different, but small numbers |
| Daragon et al. [1995] [36] | 50 persons -DISH >60yrs 50 controls - matched sex, age, weight, height |
Resnick | No difference | No difference | No difference in glucose tolerance | No association DISH and Dbs / hyperglycaemia. |
| Vezyroglou et al. [1996] [55] | 100 DISH 100 controls, matched age, sex, BMI, excess body weight |
Resnick | No difference | 22% in DISH, 3% in Controls [p<0.0001] |
Increased dyslipidemia /hyperuricemia and DM in DISH [p<0.0001] |
|
| Kiss et al. [2002] [25] | 69 M / 62 F -DISH; 69 M/62 F men /women - spondylosis | Resnick | DISH =19.8% Control = 9.1% [p<0.05] |
DISH =19.8% Control = 9.1% [p<0.05] |
NS | Significant association between DISH and diabetes |
| Mader et al. [2009] [27] | 13 M / 34 F DISH; 48 age-sex matched controls | Resnick | NS | DISH =49% Control = 33% NS |
DISH =40% Control = 10% Fasting glucose >110 mg/dL [p<0.05] |
Significant association between DISH and hyperglycaemia |
| Eckertova et al. [2009] [56] | 20 M, 9 F-DISH, 8 M, 9 F- non-DISH, matched for age, BMI. | Resnick | DISH = 41.4% Control =7.8% [p<0.05] |
NS | DISH = 41.4% Control =7.8% [p<0.05] |
Significant association between DISH and hyperglycaemia |
| Zincarelli et al. [2012] [40] | DISH 105 M / 27 F Non-DISH 231 M /73 F |
Resnick | No difference in rates of T2DM or fasting blood glucose >100mg/dl | All patients had severe cardiac disease –no healthy controls |
M = males, F = females, GT =glucose tolerance, IGT = Impaired glucose tolerance, T1DM = Type 1 diabetes mellitus, T2DM = Type 2 diabetes mellitus, NS = not stated, Dbs =diabetes, “Forestier” indicates that diagnosis based on typical features of Forestier et al. description [11].