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. 2014 Aug 28;171(23):5195–5208. doi: 10.1111/bph.12669

Figure 7.

Figure 7

UniPR129 inhibits in vitro angiogenesis in HUVECs without cytotoxic effects. (A, B) HUVEC seeded on Matrigel were treated with UniPR126, UniPR129 or dasatinib, and images were taken 15 h later. The number of polygons is relative to 1% DMSO, which was used as the control. The histogram shows the means of at least three independent experiments ± SEM. One-way anova followed by Tukey's post-test was performed to compare the 1% DMSO control to all other conditions. *P < 0.05, **P < 0.01. (C, D) HUVEC were incubated for 15 h with UniPR126 or UniPR129 at the indicated concentrations in culture medium without FBS, but supplemented with 2% low serum growth supplement. Data are the means of at least three independent experiments ± SEM. One-way anova followed by Dunnett's post-test was performed to compare the 1% DMSO control (100%, not shown) to all other conditions for the MTT assay in (C) and the 1% DMSO control (0%, not shown) to all other conditions for the LDH assay in (D). *P < 0.05, **P < 0.01.