Table 2.
Pharmacokinetic parameters of exendin-4, liraglutide and conjugate 7 in Sprague Dawley rats
| Samples | Tmax (h) | Cmax (ng·mL−1) | AUCinf (ng·h·mL−1) | t1/2 (h) | MRT (h) |
|---|---|---|---|---|---|
| Exendin-4 | 0.4 ± 0.1* | 850 ± 25.6 | 3 196 ± 981**** | 2.5 ± 1.2** | 3.9 ± 1.3** |
| Liraglutide | 1.9 ± 0.2 | 875 ± 21.4 | 17 702 ± 870** | 14.9 ± 0.9 | 20.7 ± 1.1 |
| Conjugate 7 | 3.1 ± 1.3 | 865 ± 62.3 | 29 615 ± 4 155 | 22.9 ± 7.2 | 32.9 ± 10.1 |
Data shown are the means ± SD (n = 3).
*
P < 0.05,
**
P < 0.01,
****
P < 0.0001,
compared with conjugate 7. AUCinf, area under the curve from zero to infinity; Cmax, maximum plasma concentration; MRT, mean residence time; Tmax, time to reach maximum plasma concentration; t1/2, elimination half-life.