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. 2014 Sep 5;171(23):5295–5312. doi: 10.1111/bph.12836

Figure 1.

Figure 1

Chemical structures of compounds used in the present study. CCPA, NECA and LUF5519 are ribose-containing adenosine A1 receptor agonists, whereas LUF5834 is a non-ribose agonist (Lohse et al., 1988; Müller, 2001; Beukers et al., 2004); PD81,723 and BC-1 are allosteric enhancers for adenosine A1 receptor agonists (Romagnoli et al., 2008). LUF6232, LUF6234 and LUF6258 are in-house synthesized bitopic ligands for the adenosine A1 receptor with four-, five- and nine-carbon linker, respectively (Narlawar et al., 2010). LUF7161 and LUF7160 are newly synthesized monovalent ligands with five-atom linker and nine-atom linker respectively.