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. 2014 Sep 5;171(23):5295–5312. doi: 10.1111/bph.12836

Figure 6.

Figure 6

(A) [3H]-DPCPX competition association assay in the absence or presence of unlabeled LUF5519 with or without 10 or 33 μM PD81,723. (B) [3H]-DPCPX competition association assay in the absence or presence of unlabelled LUF6232 with or without 10 or 33 μM PD81,723. (C) [3H]-DPCPX competition association assay in the absence or presence of unlabelled LUF6234 with or without 10 or 33 μM PD81,723. (D) [3H]-DPCPX competition association assay in the absence or presence of unlabelled LUF6258 with or without 10 or 33 μM PD81,723. (E) [3H]-DPCPX competition association assay in the absence or presence of unlabelled LUF7161 with or without 10 or 33 μM PD81,723. Data were fitted to the equations described in the methods to calculate the kon (k3) and koff (k4) values of unlabelled ligands by using the k1 and k2 values of [3H]-DPCPX. Representative graphs from one experiment performed in duplicate (see Table 6 for kinetic values).