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Effect of morphine on tail immersion test in PPARγ knockout (KO) and wild-type (WT) mice. Each line was divided into two groups containing (n = 10/group): groups 1 (WT/veh) and 2 (KO/veh) received morphine vehicle; groups 3 (WT mor) and 4 (KO mor) received morphine at the dose of 15 mg·kg−1. Significantly different from respective control vehicle-treated mice: *P < 0.05 and ***P < 0.0001. Significant difference between KO (mor) and WT (mor) mice: ###P < 0.0001.
