Figure 1.

D-criterion predicted by the different software tools for the warfarin phamacokinetics model compared with simulated D-criterion calculated from the inverse of the empirical covariance matrix. NONMEM first-order conditional estimation method with interaction (NM FOCEI) is calculated from the estimates using the first-order conditional estimation method with interaction in NONMEM. The Monolix criterion is calculated from the estimates using the SAEM algorithm in Monolix. () block diagonal, () full and () simulated