Table 1.
Available features in the software tools available for population design evaluation
| Feature | Software | ||||
|---|---|---|---|---|---|
| PFIM | PkStaMp | PopDes | PopED | POPT | |
| Language | R | Matlab | Matlab | Matlab FreeMat | Matlab FreeMat |
| Available on website | ✓ | ✓ | ✓ | ✓ | |
| Library of PKPD models | ✓ | ✓ | ✓ | ✓ | ✓ |
| User-defined models | ✓ | ✓ | ✓ | ✓ | ✓ |
| Multiresponse models | ✓ | ✓ | ✓ | ✓ | ✓ |
| Designs differ across responses | ✓ | ✓ | ✓ | ✓ | ✓ |
| ODE models | ✓ | ✓ | ✓ | ✓ | ✓ |
| Full FIM | ✓ | ✓ | ✓ | ✓ | – |
| Full covariance matrix for Ω | – | ✓ | ✓ | ✓ | – |
| Full covariance matrix for Σ | – | – | ✓ | ✓ | – |
| IOV | ✓ | – | ✓ | ✓ | – |
| Discrete covariates/power | ✓/✓ | – | ✓/– | ✓/✓ | ✓/– |
Abbreviations are as follows: FIM, Fisher information matrix; GUI, graphical user interface; IOV, interoccasion variability; ODE, ordinary differential equation; PKPD, pharmacokinetic–pharmacodynamic; Σ, residual covariance matrix; Ω, interindividual covariance matrix.