Table 3.

Model parameters for hepatitis C virus pharmacokinetic–pharmacodynamic model

Parameter	Value
p (fixed)*	100
d (day−1) (fixed)*	0.001
e (ml day−1) (fixed) *	1E-07
s (ml−1 day−1) (fixed)*	20 000
βka (day−1)	0.80
βke (day−1)	0.15
βVd (ml)	100 000
(μg ml−1)	0.00012
βn	2
βδ (day−1)	0.20
βc (day−1)	7
	0.25
	0.25
	0.25
	0.25
	0.25
	0.25
	0.25
	0.04
	0.04

Abbreviations are as follows: c, rate constant of elimination of viral particles; EC₅₀, drug concentration in the blood at which the drug is 50% effective; ka, rate constant of absorption; ke, rate constant of elimination; n, Hill coefficient; Vd, volume of distribution; β, fixed effects; δ, rate constant of elimination of infected cells; , residual variance for the pharmacodynamic response; , residual variance for the pharmacokinetic response; ω², interindividual variance.

^*Parameters are defined in Examples section.