Table 4.
Fisher information matrix (FIM) predicted relative standard errors (RSEs) (%) for warfarin pharmacokinetics model with the various software tools compared with empirical RSEs (%)
| Parameter | Block diagonal FIM | Full FIM | Simulations | |
|---|---|---|---|---|
| PFIM/PkStaMp/PopDes/PopED/POPT | PFIM/PkStaMp/PopDes/PopED | NONMEM | MONOLIX | |
| βka | 13.9 | 4.8 | 13.6 | 13.8 |
| βCL/F | 4.7 | 3.6 | 4.9 | 4.8 |
| βV/F | 2.8 | 2.6 | 2.7 | 2.8 |
 |
25.8 | 26.5 | 26.6 | 28.1 |
 |
25.6 | 26.3 | 26.1 | 26.6 |
 |
30.3 | 30.9 | 32.4 | 30.8 |
| σ2 | 11.2 | 12.4 | 10.9 | 11.0 |
Abbreviations are as follows: CL/F, apparent clearance of the warfarin; ka, constant of absorption of the warfarin; V/F, apparent volume of the warfarin; β, fixed effects; σ2, residual variance; ω2, interindividual variance.