Figure 6.

Internalization of (A) CHO-S1P1 and (B) CHO-S1P3 cells in response to FTY720-P following a 60 min incubation period and recovery of cell surface receptors following a subsequent 3 h washout. Internalization assays were performed as described in the methods, data points are the means of at least three determinations from multiple experiments. Statistical analysis by two-way anova and Dunnett's post-test versus unstimulated control. Significance: ***P < 0.001, **P < 0.01 within each group is displayed.