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. 2014 Oct 24;171(21):4831–4849. doi: 10.1111/bph.12859

Figure 3.

Figure 3

Dynamics of the roscovitine-dependent restoration of F508del-CFTR activity in CF15 cells. (A) Time dependence of roscovitine correction. CF15 cells incubated for different durations with roscovitine and stimulated by forskolin/genistein. (B) Persistence of correction. CF15 cells were treated for 2 h with 100 μM roscovitine and F508del-CFTR activity was assayed at different times after washout. CFTR-dependent response was induced by forskolin 10 μM + genistein 30 μM. n = 4 for each condition. ***P < 0.001; **P < 0.01; *P < 0.05; ns, not significant.