Figure 3.

PGE₂, EP₂ and EP₄ receptor agonist increase vascular diameter in vivo. (A) Representative pictures of PGE₂-induced vascular diameter increase. Vascular diameter was measured as indicated by the red double-headed arrows. A, indicates artery and V indicates vein. Scale bar, 50 μm. (B) Effect of PGE₂ and EP_2-4 receptor agonists on vascular diameter of proximal vessels (n = 4). (C) Effect of PGE₂ and EP_2-4 receptor agonists on vascular diameter of distal vessels (n = 4). (D) Content of cAMP in sections of endothelium-denuded mouse aorta. The sections were treated with PGE₂ or EP_2-4 receptor agonists (n = 4). *P < 0.05, **P < 0.01 significantly different from the results of the vehicle treatment. Data are presented as means ± SEM.