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. 2014 Sep 5;171(21):4914–4926. doi: 10.1111/bph.12822

Figure 3.

Figure 3

Effects of bupivacaine (50 μM) and quinidine (30 μM) on Kv1.5 + Kvβ1.3 channels in cells that have been treated with calphostin C or bisindolylmaleimide II. (A) Current recordings and I–V relationships obtained in the absence and presence of bupivacaine in cells pretreated with calphostin C. (B) Current recordings and I–V relationships obtained in the absence and presence of quinidine in cells pretreated with calphostin C. (C) Current recordings and I–V relationships obtained in the absence and presence of bupivacaine in cells pretreated with bisindolylmaleimide II. (D) Current recordings and I–V relationships obtained in the absence and presence of quinidine in cells pretreated with bisindolylmaleimide II. The blockade induced by both drugs was measured at the end of the pulse at +60 mV. Each point represents the mean ± SEM of six and five experiments respectively.