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(A,C) Bupivacaine- and (B, D) quinidine-induced effects on the deactivation kinetics of (A, B) calphostin C- and (C, D) bisindolylmaleimide II-treated Kv1.5 + Kvβ1.3 channels. The currents obtained after applying the protocol outlined at the top of the figure are shown. The tails were superimposed (top) and normalized (bottom) to show the similar deactivation kinetics in the absence and presence of the drugs.
