Figure 7.
LXA4 inhibits the proliferative activity of endometriotic lesions and the production of IL-6, MCP-1 and VEGF in EM mice. (A) LXA4 suppressed the growth of the endometriotic lesions in EM mice. Three days before the EM induction, the LXA4 group was i.p. injected LXA4 at a dose of 5 μg·kg−1 on a daily basis for 24 days. Arrows indicate endometriotic lesions. The weight (B) and size (C) of endometriotic lesions were significantly reduced by LXA4 treatment. Horizontal bars represent the mean weight of endometriotic lesions. *P < 0.05. (D and E) The mRNA expressions of IL-6, MCP-1 and VEGF in both endometrial tissues and peritoneal cavity cells were detected by real-time PCR. (F) Concentrations of IL-6, MCP-1 and VEGF in peritoneal fluids were measured by elisa. Results are expressed as mean ± SEM of at least three independent experiments (*P < 0.05, **P < 0.01, ***P < 0.001).