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. 2014 Oct 24;171(21):4955–4969. doi: 10.1111/bph.12819

Figure 2.

Figure 2

Identification of the binding partner (OX40 or OX40L) by assessing the amount of OX40L (top) or OX40 receptors (bottom) bound after incubations of the candidate compounds with OX40 receptors or OX40L, respectively, and addition of the protein binding partner (OX40L or OX40) only after a wash-out. All tested compounds bind to OX40 receptors, while only the promiscuous PPI inhibitor eythrosine B (ErB) binds to OX40L. Data are average ± SD (normalized to percent binding) for n = 3 independent experiments with triplicate for each condition.