Figure 5.

Three-dimensional surface representation of the activation effect on OX40 by a combination of full agonist OX40L and partial agonist 4 (CVN) in sensor cells with an NF-κB reporter (A). Purple dots represent experimental data and the surface calculated values by the corresponding fitted model (Eq. 1983). Concentrations are on the horizontal axes and are on log scales. The bottom figure (B) shows a corresponding two-dimensional representation (essentially equivalent with a cross-sectional view of the top figure from left, front) with a linear concentration scale.