Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2015 Jan 14;5:522. doi: 10.3389/fphys.2014.00522

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright © 2015 Demetrius, Magistretti and Pellerin.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

PMC Copyright notice

Brain pathological evolution to Alzheimer's disease with age according to the β-amyloid cascade hypothesis. Amyloid Precursor Protein (APP) gene mutations present in all neurons will cause the appearance in the most vulnerable neurons of NeuroFibrillary Tangles (NFT) in asymptomatic patients (YOUNG). With time, β-amyloid plaques will form and some neurons will eventually die (OLD). Progressively, more and more neurons will enter this process leading to the signs of cognitive decline characteristic of Alzheimer's disease.