. Author manuscript; available in PMC: 2015 Jan 14.

Published in final edited form as: J Neurol. 2006 Mar 6;253(6):707–713. doi: 10.1007/s00415-006-0091-5

Table.

Clinical and MRI findings in patients with CM1 and clinical signs and symptoms of cervico-thoracic syringomyelia. On recent MRI studies, Group A patients do not have syrinxes and Group B patients have narrow syrinx cavities

Group Patient number	A														B
Group Patient number	1	2	3	4	5	6	7	8	9	10	11	12	13	14	1	2	3	4	5	6	7	8	9	10	11	12	13	14	15
Age	55	48	27	61	37	43	42	52	45	51	45	57	19	47	50	64	64	75	42	47	41	47	45	45	48	63	46	46	60
Age at symptom onset	47	28	20	48	30	22	12	32	12	29	10	20	11	17	21	24	44	30	12	31	37	17	11	17	21	16	14	18	39
Segmental signs:
dysesthetic pain	+							+	+							+				+	+	+		+	+	+	+	+	+	p < 0.017
sensory loss	+	+		+	+	+	+	+	+	+	+	+	+	+	+	+	+	+	+	+		+	+	+		+	+	+	+
trophic disturbance	+		+	+							+					+		+					+		+	+	+	+	+
muscular atrophy			+						+	+		+				+		+	+		+		+	+
weakness	+	+		+	+	+	+	+	+	+	+	+	+	+	+	+	+	+	+	+	+	+	+		+	+	+	+	+
Long tracts signs
pyramidal signs					+	+	+				+	+	+	+	+	+	+		+	+	+	+	+	+	+		+	+	+	p < 0.036
impaired position sense				+								+				+	+	+	+				+
FM level signs
suboccipital headache																	+									+
nystagmus						+	+								+						+	+				+		+
ataxia							+	+		+								+	+		+	+				+	+
dizziness/vertigo	+			+		+	+										+					+	+			+
impaired CN IX, X								+										+			+	+			+
Scoliosis/kyphosis							+		+		+		+	+	+	+		+	+		+		+	+			+		+
MRI features
cerebellar cisterns
obliterated	+		+			+	+	+	+	+	+	+	+	+		+	+	+	+	+	+	+	+	+	+	+	+		+
small		+		+	+										+													+
tonsillar herniation (mm)																												5
basilar invagination		+	+	+	+		+	+		+		+	+	+	+			+		+			+	+	+
Cervicomedullary kinking		+																	+		+	+		+
short supraocciput	+		+				+			+	+					+			+		+	+		+	+	+	+	+	+
short clivus			+				+								+				+	+	+	+			+			+
Boogard’s angle increased				+								+	+		+	+	+	+	+		+	+	+	+	+	+	+	+		p < 0.001
platybasia	+			+	+						+	+	+								+	+					+	+	+
Obliterated CSF space
Ventral Foramen magnum									+			+			+		+	+			+	+	+	+	+		+			p < 0.014
Dorsal Foramen magnum	+		+			+	+	+					+		+	+	+			+	+	+	+	+	+	+	+	+	+	p < 0.016
Spinal cord AP diameter (mm)	6.5	11	12	10	11	9	6	8.5	10	6	11	8.5	7	10	8.5	6	6	7.5	7	9.5	6.5	8	10	9.5	9	8	7.5	9.5	15
Syrinx AP diameter (mm)															1	1	3	3	3	3	1	2	4	1	3	2	4	1	3
Spontaneous syrinx drainage															+						+	+