Table 2.

NK-1 receptor BP for each group in subcortical and cortical regions of interest (A). Group differences in NK-1 Receptor BP (B).

Region	A)						B)
	Healthy control		IBD		IBS		Healthy control vs IBD					Healthy control vs IBS					IBS vs IBD
	Mean BP	SD	Mean BP	SD	Mean BP	SD	F	P-value	ES+	95% CI		F	P-value	ES+	95% CI		F	P-value	ES+	95% CI
										−	+				−	+				−	+
Subcortical ROIs
Putamen	3.96	0.42	2.99	0.57	3.30	0.81	11.00	0.003*	2.06	−3.20	−0.91	5.04	0.034	1.09	−2.07	−0.10	1.15	0.294	0.47	−1.41	0.47
Caudate nucleus	2.97	0.59	2.21	0.60	2.38	0.80	5.86	0.023	1.35	−2.38	−0.33	3.47	0.075	0.89	−1.86	0.08	0.31	0.583	0.26	−1.18	0.67
Nucleus accumbens	3.83	0.48	3.09	0.55	3.54	0.44	10.06	0.004*	1.52	−2.57	−0.47	1.53	0.228	0.67	−1.62	0.28	3.74	0.065	0.96	0.74	2.95
Globus pallidus	1.93	0.26	1.56	0.28	1.74	0.27	8.42	0.008*	1.45	−2.49	−0.41	2.14	0.157	0.76	−1.72	0.20	2.08	0.163	0.69	−1.65	0.26
Thalamus	1.14	0.23	0.95	0.17	1.07	0.21	3.75	0.065	1.00	−1.98	−0.02	0.47	0.500	0.34	−1.27	0.59	1.57	0.222	0.67	−1.62	0.28
Hippocampus	1.14	0.13	0.91	0.15	1.03	0.18	10.30	0.004*	1.74	−2.82	−0.65	2.61	0.119	0.74	−1.70	0.21	2.54	0.124	0.77	−1.73	0.19
Amygdala	1.81	0.20	1.42	0.25	1.65	0.20	14.20	0.001*	1.83	−2.93	−0.73	2.45	0.130	0.85	−1.81	0.12	4.85	0.037	1.08	−2.07	−0.09
Weighted average	2.30	0.26	1.78	0.30	1.97	0.42	10.95	0.003*	1.96	0.006	0.661	4.24	0.046	1.00	−0.14	0.52	1.45	0.240	0.55	−0.14	0.52
Cortical ROIs
dlPFC	1.35	0.18	1.29	0.16	1.39	0.13	0.47	0.500	0.37	−1.31	0.56	0.36	0.552	0.27	−0.66	1.20	1.65	0.211	0.73	−1.68	0.23
vlPFC	1.57	0.21	1.51	0.19	1.59	0.20	0.41	0.528	0.32	−1.25	0.61	0.05	0.824	0.10	−0.82	1.03	0.75	0.395	0.43	−1.37	0.50
mPFC	1.43	0.17	1.35	0.17	1.45	0.15	1.34	0.277	0.50	−1.44	0.44	0.07	0.788	0.13	−0.79	1.06	1.92	0.179	0.66	−1.61	0.29
Perigenual ACC	1.70	0.18	1.46	0.17	1.54	0.17	8.73	0.007*	1.45	−2.49	−0.42	4.19	0.05	0.97	−1.95	0.007	0.83	0.373	0.50	−1.44	0.44
Anterior MCC	1.70	0.20	1.46	0.19	1.49	0.14	8.20	0.009*	1.30	−2.32	−0.29	5.86	0.023	1.29	−2.31	−0.27	0.20	0.662	0.19	−1.12	0.74
PCC	1.69	0.15	1.60	0.21	1.67	0.21	1.18	0.289	0.52	−1.46	0.42	0.07	0.792	0.12	−1.04	0.81	0.67	0.422	0.36	−1.29	0.57
Anterior insula	1.72	0.20	1.52	0.21	1.62	0.27	3.43	0.077	1.03	−2.02	−0.05	0.82	0.375	0.45	−1.38	0.49	0.90	0.353	0.44	−1.37	0.50
Mid insula	1.76	0.20	1.50	0.19	1.64	0.27	5.87	0.023	1.41	−2.45	−0.38	1.09	0.306	0.54	−1.48	0.41	1.90	0.181	0.64	−1.58	0.31
Posterior insula	1.77	0.19	1.51	0.20	1.65	0.23	7.20	0.013	1.41	−2.45	−0.38	1.56	0.223	0.60	−1.55	0.34	2.06	0.165	0.69	−1.64	0.26
Weighted average	1.46	0.18	1.33	0.17	1.43	0.14	3.18	0.087	0.79	−0.02	0.29	0.12	0.731	0.20	−0.13	0.18	2.06	0.164	0.68	−0.05	0.27

NK-1, neurokinin-1; BP, binding potential; IBD, inflammatory bowel disease; IBS, irritable bowel syndrome; ES, effect size; CI, confidence interval; ROI, region of interest; dlPFC, dorsolateral prefrontal cortex; vlPFC, ventrolateral prefrontal cortex; mPFC, medial prefrontal cortex; ACC, anterior cingulate cortex; MCC, midcingulate cortex; PCC, posterior cingulate cortex.

^*P < 0.05 corrected;

+ Cohen's d effect size difference based on means and SDs for each region.