Table 3.

Correlation between NK-1R BP in regions of interest and: symptom severity (A); duration of illness (B); and sensitivity to thermal stimulation (C).

Region	A) Symptom severity		B) Duration of illness		C) Temperature for pain threshold
	IBD	IBS	IBD	IBS	Healthy control	IBD	IBS
	r	r	r	r	r	r	r
Subcortical ROIs
Putamen	−0.65	−0.07	−0.25	−0.76*	0.38	0.18	−0.43
Caudate	−0.63	−0.06	−0.35	−0.83*	0.44	0.42	−0.48
Nucleus accumbens	−0.39	−0.33	−0.23	−0.58	0.26	0.06	−0.47
Globus pallidus	−0.23	−0.12	0.46	0.03	−0.25	0.06	−0.07
Thalamus	−0.45	0.28	0.38	−0.19	−0.48	−0.19	−0.25
Hippocampus	−0.19	−0.34	−0.13	−0.28	−0.86**	0.26	−0.37
Amygdala	−0.61	−0.49	−0.07	−0.67	−0.40	0.28	−0.22
Average of ROIs	−0.66	−0.07	−0.19	−0.72*	0.14	0.26	−0.45
Cortical ROIs
dlPFC	−0.09	0.29	0.44	−0.59	−0.18	0.11	−0.94**
vlPFC	−0.23	0.15	0.06	−0.63	−0.30	−0.17	−0.70
mPFC	−0.49	0.11	0.23	−0.68	−0.26	−0.09	−0.80*
Perigenual ACC	−0.77*	0.21	−0.02	−0.64	−0.26	0.01	−0.63
Anterior MCC	−0.69*	0.10	0.27	−0.65	−0.22	0.08	−0.52
PCC	−0.74	0.00	0.17	−0.59	−0.07	−0.05	−0.80*
Anterior INS	−0.90**	0.16	0.10	−0.80*	−0.24	0.09	−0.58
Mid INS	−0.90**	0.08	0.16	−0.85*	−0.22	0.20	−0.51
Posterior INS	−0.75	0.16	0.15	−0.83*	−0.38	0.06	−0.61
Average of ROIs	−0.63	0.05	0.22	−0.70	−0.29	0.06	−0.62

NK-1, neurokinin-1; BP, binding potential; IBD, inflammatory bowel disease; IBS, irritable bowel syndrome; ROI, region of interest; dlPFC, dorsolateral prefrontal cortex; vlPFC, ventrolateral prefrontal cortex; mPFC, medial prefrontal cortex; ACC, anterior cingulate cortex; MCC, midcingulate cortex; PCC, posterior cingulate cortex; INS, insula. Corrected within-group correlations:

^*P < 0.05;

^**P < 0.01.