TABLE 1.
Infusate and observation characteristics in study primates*
Animal No. | Striatal Side | Vi (μl) | Infusate | Final Vd/Vi Ratio on Imaging† | Final Vd/Vi Ratio on QAR‡ |
---|---|---|---|---|---|
1 | lt | 63.2 | 5 mM Gd-DTPA | 7.94 | NA |
rt | 65.2 | 1 mM Gd-DTPA | 3.37 | NA | |
2 | lt | 38.4 | 5 mM Gd-DTPA | 6.44 | NA |
rt | 36.3 | 1 mM Gd-DTPA | 2.25 | NA | |
3 | lt | 23.3 | 5 mM Gd-DTPA | 6.89 | NA |
rt | 21.4 | 1 mM Gd-DTPA | 1.33 | NA | |
4 | lt | 46.5 | 5 mM Gd-DTPA & 14C-sucrose | 6.44 | 5.76 |
rt | 46.7 | 1 mM Gd-DTPA & 14C-sucrose | 2.23 | 6.46 | |
5 | lt | 51.3 | 5 mM Gd-DTPA & 14C-dextran | 6.31 | 6.33 |
rt | 54.6 | 1 mM Gd-DTPA & 14C-dextran | 1.73 | 5.42 |
NA = not applicable.
Vd determined by 3D MR imaging volumetric analysis.
Vd determined by quantitative autoradiography.