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. 2015 Jan 14;5:469. doi: 10.3389/fgene.2014.00469

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Copyright © 2015 Emperador, Pacheu-Grau, Bayona-Bafaluy, Garrido-Pérez, Martín-Navarro, López-Pérez, Montoya and Ruiz-Pesini.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Paromomycin effect on OXPHOS proteins of MRPS12 transfected cells. (A) Mitochondrial translation products (right panel) and loading controls (left panel). AR, AL, GR, GL, ARp, ALp, GRp, and GLp code for 12S rRNA m.1555A-MRPS12^R68R, 12S rRNA m.1555A-MRPS12^R68L, 12S rRNA m.1555G-MRPS12^R68R, 12S rRNA m.1555G-MRPS12^R68L cells grown without or with paromomycin (p), respectively. (B) CIV/CS ratio of wild-type (m.1555A 12S rRNA) and mutant (m.1555G 12S rRNA) osteosarcoma 143B cybrids exposed or not to paromomycin. (C) CIV/CS ratio of wild-type (m.1555A 12S rRNA) and mutant (m.1555G 12S rRNA) osteosarcoma 143B cybrids that overexpress the R68 or L68 MRPS12 variants exposed or not to paromomycin. Asterisks denote P ≤ 0.0414.