Table II.
MicroRNA signature differentiating HR versus LR MDS.
| MicroRNA | Parametric P value |
Fold change |
Chromosomal location |
|---|---|---|---|
| MIR181C | <1e-07 | 22·72 | 19p13.13 |
| MIR181A | <1e-07 | 19·95 | 19q33.3 |
| MIR181B | 2E-07 | 14·25 | 1q32.1 |
| MIR181D | <1e-07 | 13·88 | 19p13.13 |
| MIR221 | 4E-07 | 12·07 | Xp11.3 |
| MIR376B | 0·024925 | 4·99 | 14q32.31 |
| MIR125B | 9E-07 | 4·27 | 11q24.1 |
| MIR155 | 0·000131 | 3·62 | 21q21.3 |
| MIR130A | 0·000675 | 2·80 | 11q12.1 |
| MIR486-5P | 0·005686 | 0·14 | 8p11.21 |
The signature was predictive (misclassification error rate after 10-fold CV, <0·01). Red: up-regulated microRNAs, green: down-regulated microRNAs.