Table 1.
Demographic and clinical characteristics.
| LTA | MeDi | |||
|---|---|---|---|---|
|
| ||||
| LTA+ | LTA− | MeDi+ | MeDi− | |
| N | 21 | 24 | 18 | 27 |
| Age, y, mean (SD) | 54 (11) | 54 (11) | 54 (11) | 54 (11) |
| Female gender, % | 57% | 83% | 83% | 63% |
| Education, y, mean (SD) | 16 (2) | 16 (2) | 16 (2) | 16 (2) |
| Family history of LOAD, % positive | 62% | 79% | 72% | 70% |
| APOE ε4 status*, % positive | 33% | 50% | 53% | 36% |
| Ethnicity, % White/Non-Hispanic | 71% | 92% | 78% | 85% |
| Hypertension, % yes | 26% | 23% | 12% | 33% |
| Anthropometrics and Labs, mean (SD) | ||||
| Body mass index [unitless] | 26 (4) | 25 (4) | 24 (4) | 26 (5) |
| Hip to waist ratio [unitless] | 1.4 (0.1) | 1.5 (0.4) | 1.0 (0.3) | 1.2 (0.2) |
| Blood pressure (mm/Hg) Systolic Diastolic |
119 (15) 68 (12) |
120 (15) 74 (7) |
122 (12) 75 (8) |
119 (16) 70 (15) |
| HOMA score (mg/dl) | 1.1 (0.6) | 1.8 (2.5) | 1.8 (2.1) | 1.3 (2.1) |
| Cholesterol (mg/dl) | 207 (43) | 195 (36) | 207 (44) | 197 (35) |
| Triglycerides (mg/dl) | 86 (40) | 95 (37) | 98 (44) | 85 (33) |
| HDL/LDL [unitless] | 0.59 (0.22) | 0.51 (0.17) | 0.54 (0.16) | 0.56 (0.22) |
| Homocysteine (micromol/l) | 10.6 (2.3) | 10.0 (2.8) | 10.8 (3.1) | 9.8 (2.1) |
| Neuropsychological Tests, mean (SD) | ||||
| Mini mental state exam | 29 (1) | 29 (1) | 29 (1) | 29 (1) |
| Digit symbol substitution | 65 (11) | 61 (9) | 63 (10) | 62 (11) |
| Paired associates delayed recall | 7 (3) | 7 (3) | 7 (2) | 6 (3) |
| Paragraph delayed recall | 10 (3) | 10 (2) | 10 (3) | 10 (3) |
| Designs | 8 (2) | 8 (2) | 8 (2) | 8 (2) |
| Object naming | 55 (12) | 53 (13) | 55 (12) | 53 (13) |
| WAIS-vocabulary | 66 (9) | 62 (15) | 66 (10) | 62 (18) |
Abbreviations: MeDi = adherence to a Mediterranean-type diet (higher vs. lower, MeDi+ vs. MeDi−); LTA = engagement in leisure time activity (higher vs. lower, LTA+ vs. LTA−).