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. Author manuscript; available in PMC: 2015 Jan 14.
Published in final edited form as: Oncogene. 2013 Feb 18;33(6):702–712. doi: 10.1038/onc.2013.13

Figure 7.

Figure 7

U0126, specific inhibitor of ERK phosphorylation, inhibits growth of HNSCC. (a) Growth suppression in FaDu or FaDu-LV-miR-125b-1 cells transfected with shTACSTD2, shMYC, TACSTD2 or MYC and treated with U0126 at a concentration of 1 µm. The experiments were performed three times using triplicate samples, and average scores are indicated with error bars on the histogram (*P < 0.05). (b) Downmodulation of phospho-ERK and MYC in FaDu cells treated with U0126. (c) Suppression of TACSTD2 and MYC transfected with shTACSTD2 and shMYC in FaDu cells. (d) Overexpression of TACSTD2 and MYC in FaDu-LV-mir-125b-1 cells transfected with TACSTD2 and MYC. IB, immunoblot.