Table 1.
Differential miR expressed in the HNSCC comparing with the non-HNSCC
| MicroRNA | Chromosomal location | Fold change (HNSCC/ non-HNSCC) |
P-value |
|---|---|---|---|
| Upregulated in HNSCC | |||
| miR-146b | 10q24.32 | 171 | 3.77E-06 |
| miR-340-5p | 5q35.3 | 57 | 2.78E-10 |
| miR-15b-3p | 3q25.33 | 54 | 5.72E-11 |
| miR-135a-5p | 3q21.1 | 50 | 7.46E-12 |
| miR-16-5p | 13q14.2 | 35 | 4.35E-09 |
| miR-15b | 3q25.33 | 33 | 4.99E-08 |
| miR-486 | 8p11.21 | 25 | 7.11E-06 |
| miR-148b | 12q13.13 | 23 | 9.16E-10 |
| miR-182-5p | 7q32.2 | 7.6 | 1.36E-06 |
| miR-21 | 17q23.1 | 5.7 | 6.60E-07 |
| Downregulated in HNSCC | |||
| miR-125b-1 | 11q24.1 | 0.01 | 6.38E-11 |
| miR-145 | 5q32 | 0.01 | 5.64E-08 |
| miR-619 | 12q24.11 | 0.01 | 1.20E-14 |
| miR-618 | 12q21.31 | 0.01 | 1.23E-14 |
| miR-616 | 12q13.3 | 0.01 | 8.63E-07 |
| miR-770 | 14q32.2 | 0.01 | 2.46E-14 |
| miR-302d | 4q25 | 0.02 | 1.98E-11 |
| miR-372 | 19q13.42 | 0.03 | 1.33E-10 |
| miR-643 | 19q13.41 | 0.03 | 2.52E-09 |
| miR-340 | 5q35.3 | 0.04 | 2.03E-09 |
Abbreviations: HNSCC, head and neck squamous cell carcinoma; miR, microRNA.
List of differentially expressed miRNAs in HNSCC compared with normal tissues and normal keratinocytes. miRNAs are sorted by P-value of the univariate test (BRB tools). The first 10 genes are significant at the nominal 0.01 level of the univariate test. False discovery rate or q-value is the expected percentage of genes identified by chance.