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. 2015 Jan 13;56(1):177–184. doi: 10.1167/iovs.14-15550

Figure 6.

Figure 6

IGFBP-3 S156A plasmid DNA transfection partially reverses inhibition of apoptosis with pioglitazone. Bar graph of cleaved caspase 3 expression of REC in normal (5 mM) and high glucose (25 mM). Retinal endothelial cells in high-glucose medium were transfected with TNFα siRNA for 24 hours followed by transfection with CMV, IGFBP-3, and IGFBP-3 S156A plasmid and subsequent treatment with pioglitazone next day for 24 hours. *P < 0.05 versus untreated normal glucose control. #P < 0.05 versus untreated high glucose control. Data are mean ± SEM, N = 4.